Browsing by Subject "cancer therapy"

Now showing items 1-4 of 4

    • Article  

      Multistage nanoparticles for improved delivery into tumor tissue 

      Stylianopoulos, T.; Wong, C.; Bawendi, M. G.; Jain, R. K.; Fukumura, D. (2012)
      The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
    • Article  

      Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner 

      Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)
      The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
    • Article  

      Remodeling components of the tumor microenvironment to enhance cancer therapy 

      Gkretsi, V.; Stylianou, A.; Papageorgis, P.; Polydorou, C.; Stylianopoulos, T. (2015)
      Solid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the ...
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...